Both teams will be keen to open their account for 2021 after coming off losses in the opening round.
The Cowboys return to Townsville after they were held to zero by the Panthers in Penrith last Saturday while the Dragons were competitive against Cronulla on Sunday but fell away in the second half at Kogarah.
North Queensland and St George Illawarra are both in the early stages of the start of a new coaching reign with Todd Payten and Anthony Griffin respectively looking to put their own stamp on their side after disappointing 2020 campaigns.
